Professor Utonium, his son Ken, Blossom, the Mayor, and Ms. Bellum and Poochi find Bubbles jumping cheerfully as she is attacked by Mojo Jojo and takes them in for research.
Buttercup reluctantly joins the group. The girls are put into the same class to make them get along and they stop Mojo from hogging all the food in a restaurant.
Climbing the Walls: Professor Utonium, Mr. Mayor, Ms. Bellum and the girls inspect the tall building which will become Mayor's Tower when Mojo tries to claim it to.
Fuzzy Lumpkins: Fuzzy Lumpkins keeps driving the girls and friends away while they try to enjoy a trip to the woods.
Princess Morbucks: Classmate Princess Morbucks (Himeko) is hit by the black Z-Rays and plots to outshine the Powerpuff Girls.
Blossom is given the task of being the bodyguard of her favorite TV hero, Johnny Cosmo when Mojo threatens him.
The Amoeba Boys (now including a lady) attempt to become villains with little success.
A local shop owner and the Girl's friend, Annie is hit by black Z-rays turning her into the monster Sedusa! She attempts to glamour herself to win the heart of her friend Jason.
Buttercup trains a young kid named Justin to become a better soccer player. After falling in love with Ms. Bellum, Fuzzy decides to take her back to the woods.
Believing Blossom, Bubbles and Buttercup are planning to show off, Princess follows them to unearth their plan.
Mojo decides to steal all the cakes in the city.
Mojo decides to teach the Amoeba Boys how to become villains.
A camera thrown away by the Mayor takes out his revenge by turning New Townsville black and white.
Mojo attacks a fashion show that Blossom and Bubbles are participating in.
After a customer puts too much vinegar on the soup, black Z-Rays turns the soup into Noodlehead and forces people to eat noodles 'the right way', but the Powerpuff Girls Z are too full to stop him.
Ernie, the school newspaper's photographer, struggles to take a decent picture of the Powerpuff Girls.
The Mayor's petty argument with his brother, the Principal, causes an electric wave monster to be created.
A piano hit by black Z-Rays terrorizes the town after being played poorly by Mojo.
In order to not let their grades slip, Ms. Keane shoots down every excuse the girls have to fight Mojo.
A boy's rubber duck is lost and hit by a black Z-Ray, and Poochi decides to take care of it.
A group of vegetables take all the vegetables into space after no one eats them.
A Comedy of Terrors: A comedian tries to win the heart of a girl whose father doesn't appreciate comedy. Beetle Battle: With the help of Buttercup, Ken trains his pet beetle to defeat his rival in a beetle fighting tournament.
The Write and the Wrong Way: Miyako's pen and eraser are infected by Him's black spores. The pen likes to cause mischief, but the eraser tries to stop him. Flower Power: Him's spores infect a lonely flower, who begins to cover the town in flora.
Super Tough Girls: Him uses a manga illustrator's talent to create new monsters. Powerpuff Boys Z: Professor Utonium, Ken, and Poochie save the day when the girls are forced to stay for a test.
The Mighty Morbucks: Princess' older sister Duchess comes for a visit, with plans to outshine the Powerpuff Girls. Trading Faces: After an injury by Fuzzy, the girls end up in each other's bodies.
The Professor Gets His Cut: Him challenges the girls to retrieve three items for him if they want to see the Utonium family again. Who is Lucas Clark?: After telling Princess she has a boyfriend, Blossom does everything she can to prevent the truth from coming out.
Hoppily Ever After: Blossom lets her emotions get the better of her when she meets a frog prince. Vamp on Campus: After mistakenly believing Jason is going out with his professor, Annie turns into her alter ego and goes on a rampage.
Keane For a Break: After breaking up with her boyfriend, Ms. Keane accompanies Mojo on a trip to a hot spring. Like Giving Candy to a Baby: Him turns the Powerpuff Girls to kids.
The Happy Thought Blaster: Professor Utonium teaches the girls a new move to combat Him's pure evil. Nurse Curse: After hurting himself, Mojo prolongs his hospital stay when he falls in love with nurse.
