Ronan the Accuser of the Kree Empire arrives at Earth with Captain Mar-Vel in tow to pass judgment on whether the planet should be annexed or destroyed.
With Captain America's reputation now in tatters, the superhero and the similarly maligned Spider-Man find themselves trying to thwart a prisoner transport interception.
Captain America and friends travel to Wakanda to repair his shield, unaware that a powerful android is hunting them to capture it among other objectives.
The Enchantress offers Loki a chance to exact his revenge on Thor and the Avengers for thwarting his conquest of the Nine Realms, and uses a spell to strip Thor, Captain America, and Iron Man of their powers. Now, the helpless heroes must defeat Loki - his soul now in command of a powerful Asgardian weapon known as the Destroyer - without their abilities.
When there is a sudden exposure of a malignant virus around the Avengers mansion, the Secretary of Defense blames the team and lays siege of the headquarters.
While dealing with the Red Skull's escape with his Sleeper robots, Captain America also investigates the villain's former henchman who seems disturbingly familiar.