Blanche is mortified after taking a pregnancy test which indicates she's pregnant. Then after visiting her doctor, she learns the truth, she's beginning menopause. Meanwhile, Dorothy, Rose and Sophia go into the mink breeding business.
The house is fumigated and the girls move into a Miami Beach hotel. Previously, Blanche had won three tickets to see the opening of Burt Reynolds new movie and passes to the party held afterwards where they could meet him. However, on the evening of the opening, the hotel is raided and, mistaken as prostitutes, Dorothy, Blanche and Rose are dragged off to jail.
Dorothy dumps a depressed Stan on Blanche but then becomes incredibly jealous when Blanche and Stan hit it off. Meanwhile, Sophia and Rose begin selling sandwiches on the Boardwalk but they inadvertently make an enemy of another vendor, "Johnny No Thumbs".
The girls circulate a petition to save a 200 year old oak tree which is located on the property of the most hated woman in the neighborhood, Frieda Claxton, who wants the tree cut down.
Dorothy's old friend, Jean comes to Miami for a visit and Dorothy decides not to tell Blanche and Rose that Jean is a lesbian. Then, after spending time with Rose, Jean begins to fall for her. Meanwhile, a new VCR, prompts Sophia to rent ""dirty movies.""
Blanche's father comes to Miami for a visit and has an announcement he's engaged to be married. Blanche is thrilled until she meets his fiancee who happens to be younger than herself. Meanwhile, Dorothy and Rose enter a song writing contest.
Dorothy's son, Michael, and Rose's daughter, Bridget, each come to Miami for a visit and each of them become a little too friendly for Dorothy and Rose's liking. Meanwhile, Blanche hurts her back in aerobics class.
The girls' dream vacation in the Caribbean turns out to be far from what was advertised in the brochure. While the girls are away, Sophia romances the gardener.
Laid off from work, Dorothy searches for part-time work which leads to Blanche getting her a job at the museum. Then fur flies when Dorothy is handed the job of organizing a banquet, the duty Blanche was hoping for. Meanwhile, Rose finds a stray dog at the supermarket.
Rose places an ad in the personals column and she is let down when she doesn't hear an immediate response. This leads Blanche and Dorothy to begin responding under the name Isaac Newton.
For Sophia's birthday, Dorothy flies in her sister, Angela from Sicily as a surprise. However, Dorothy's the one whose surprised when Sophia's reaction is that of disgust.
Dorothy feels sympathy for Stan when he tells her he's going to have open heart surgery. However that sympathy fades when she learns of his many infidelities while they were married.
Rose is convinced she died during a throat spasm. This leads her to live her life to the hilt, totally disrupting the other girls lives. Then, when the girls complain about her new lifestyle, Rose moves out.
Sophia readies herself for participating in a walkathon. Meanwhile, Dorothy, Blanche and Rose babysit for the walkathon participants children but when the event is over, a baby is left unclaimed.
When the girls learn that a number of relatives are going to be visiting, they reminisce about times they've had to share a bed and strange places they've had to sleep, including a train station.
Blanche and Rose plan a nice dinner at the house for Dorothy and her new boyfriend whom she later learns is a priest. She later gets another shock when she learns he plans to leave the church.
Sophia's sister, Angela arrives in Miami for a visit and decides to move there but while she's looking for an apartment Dorothy invites her to stay with the girls. This ticks off Sophia since she thinks that Angela is after everything that she has.
Blanche is convinced that her beauty is fading after attending her high school reunion and discovers many of classmates have had face lifts. Meanwhile, Rose is making a home movie for class she's taking.
While Dorothy and Rose are planning a hospital charity banquet, Blanche falls for Jake, the caterer hired for the event. She quickly learns he's more blue jeans than a black tie which prompts her to foolishly put a stop to their romance.
Dorothy's daughter, Kate is coming for a visit and has a big announcement. Dorothy is excited when she thinks the announcement is going to be that Kate is pregnant. However, when Kate arrives, her announcement is far from exciting. Meanwhile, Blanche and Rose stay up and watch an "I Love Lucy" marathon.
While preparing for a friend's birthday party, the girls recall past birthdays, including Rose's surprise birthday party for Dorothy, a surprise birthday party for Blanche and a memory of Sophia's birthday involving her late-husband Sal.
In this pilot for another series (Empty Nest, obviously the concept was retooled), the girls' friend Renee is feeling depressed and lonely with her children grown up and moved out and her husband's workaholic habits.
