Season 21

Also: a look at actor Charlie Sheen's home life at his estate. Correspondents: Keith Morrison and Jeff Rossen.

Hidden cameras reveal how teens react to different bullying situations.

Dennis Murphy investigates the mysteries surrounding the shooting deaths of two family members in a still Georgia hamlet.

Correspondent Hoda Kotb delves into a four-year international custody battle.

When Amber Dubois vanished in San Diego County, a search turned up nothing. Then, a year later, Chelsea King disappeared in a neighboring town. Tonight, Keith Morrison reports on the mystery of the missing California teens.

Reporter Keith Morrison explores the plight of unwanted children in Moscow, recounting the story of an institutionalized boy whose life took a positive turn after years of rejection.

Rob Stafford investigates the cold-blooded slaying of an expectant mother. In a second report, Keith Morrison tracks the work of a dauntless detective and a determined attorney to solve the cold-case killing of a 21-year-old woman.

Chris Hansen files a report on Mexico's drug war. Hansen joins with Mexican federal officers on a secret assignment to capture kingpins and relates the story of a hit man leading a double life. Also: a woman who sacrificed all to battle corruption.

Dennis Murphy delves into how two brothers were killed under odd conditions but at different times and in separate locations. In addition, Keith Morrison details a family hunting trip in Newfoundland that went terribly wrong.

NBC’s Dennis Murphy traces the journey of Kate Middleton from commoner to Her Royal Highness.

The impact of the recent tornadoes, severe thunderstorms and flash-flood warnings in the United States; reports from London include behind-the-scenes coverage of the royal wedding.

First lady Michelle Obama and Dr. Jill Biden talk about their ``Joining Forces'' campaign, Rep. Gabrielle Giffords' staff discuss the shooting, singer Steven Tyler talks about success and drug addiction, ``Bridesmaids'' cast members.

A man who was arrested and tried three times for the death of his wife of four months talks about the case.

David Goldman, whose five year battle for custody of his son made international news, talks about life since being reunited with his child.

A doctor disappears while on vacation with his wife, leaving her $6 million in debt.

Hidden cameras reveal how quickly, honestly and efficiently repairmen do their jobs.

A young woman teams with a U.S. Marshal to find the man who murdered her mother 18 years earlier.

Chris Hansen visits a shop in New York that sells bath salts, a new designer drug.

Keith Morrison reports the story of an Oklahoma pastor's son and daughter who endure a remarkable road to recovery after witnessing a terrible family tragedy.

Richard Engel reports on the Battle of Wanat, one of the worst casualty counts of the Afghanistan war that left nine soldiers dead and 27 injured the families of one platoon come together to grieve and uncover why their sons died.

A successful young man is shot down in front of his Philadelphia home. A woman finds her way back to her family after being kidnapped 30 years earlier.

The citizens of a Wisconsin town come together to renovate a family's home.

Hidden cameras reveal how teens react to different bullying situations.

Josh Mankiewicz probes the cold-case murder of a casino-sales executive.

New details and courtroom dramas key Dennis Murphy's update on the Caylee Anthony case. Anthony's young mother, Casey Anthony, is accused of murdering the toddler in 2008.

When a 38-foot empty Donzi boat is found making circles in the ocean with nobody on board, a mystery begins in the Bahamas. While hundreds of Americans die every year from accidental carbon monoxide, NBC News’ Kate Snow previews one case that police say was not an accident, but potential murder.

Lester Holt takes viewers into Chicago communities, children who grow up quickly and die young.

An Oregon family struggles with the mysterious disappearance of their daughter, and Kate Snow looks into the investigation that plagued family and community.

A year after being taken captive by Somali pirates, Captain Richard Phillips talks with Matt Lauer about his harrowing experience and brave rescue.

A young detective investigates a college student's death; chronicling the events of the Casey Anthony murder trial.

Chris Hansen goes under cover with California lottery investigators; testing the integrity of lottery clerks in New York.

When a woman goes missing in a small town in rural Michigan, her husband becomes the primary suspect. But eyewitnesses and surveillance cameras support his alibi that he was in Virginia the day she disappeared - more than 700 miles away.

A year-long investigation into children migrant workers.

A 24-year-old U.S. citizen targeted by kidnappers in South America and taken; the story of a man who is suspected of murdering his wife in a fire.

Chris Hansen goes face-to-face with a man, who along with other conspirators, cheated a Connecticut woman out of her life savings through an internet scam.

A former homecoming queen comes under suspicion after her husband is found stabbed to death and an affair with the local youth pastor is uncovered.

Brian Williams documents a day behind-the-scenes on Capitol Hill where viewers will get an unprecedented look at life under the U.S. Capitol dome.

An admired sports editor is killed on Halloween night.

Tom Brokaw reports the story of three different families throughout the war in Iraq.

A couple's romantic night at the Hudson Palisades ends in a tragic fall, leaving officials questioning whether or not it was an accident.

The murder of a husband exposes the shocking secret life he had with his wife. They were swingers.

Lester Holt reports the story of three American women who face the Great Recession and their own worst fears.

A young father fights desperately across the United States for custody of his baby girl. Plus the story of Nancy Cooper who went missing while jogging in a suburb of Raleigh, North Carolina.

Watch amazing animals and the true stories behind some of the most popular videos on the web.

A serial killer stalks human prey through America's national forests until clues help trigger a multi-state manhunt.

Former Vice President Dick Cheney discusses his new memoir with Jamie Gangel; Grammy award winner Miranda Lambert is interviewed by Hoda Kotb; 12-year-old author of "Heaven is For Real" sits down with Hoda Kotb to hear about his trip to heaven.

Reports from a desert in New Mexico which has become one of the largest crime scenes in history, where the remains of eleven female bodies were found buried.

When a young woman disappeared in Alaska, police looked at two brothers as suspects. Would anyone be able to breach their loyalty and find the truth?

Tom Brokaw, recaps some of the most powerful stories reported by NBC News in the days and months following the tragic assault on our nation.

An indie film-maker is connected to the case of a missing man, which started as an obsession with "Dexter". Was it a publicity stunt or something far darker?

A young Florida mother abducted at gunpoint and taken for ransom. Three failed attempts to drop the ransom put everyone on edge and no one imagined the bizarre way this crime would be solved.

A troubled marriage, then suddenly a man disappears, leaving behind a daughter and step-son. The truth from a secret kept for over eight years.

A young woman disappears following her chance encounter with a stranger on a train. Her desperate family hires a dream team of detectives to follow the mysterious trail she left behind.

A couple with the perfect marriage until Cristi was found dead in the backyard spa. And, a story-book marriage, NO lust, greed and deceit led to an elaborate murder plot that makes reality TV look like a fairytale.

In October 2009, James Arthur Ray, a renowned self-help author and speaker, held a "Spiritual Warrior" retreat in Sedona, AZ. Three people died during the retreat, and Ray was charged with manslaughter but convicted of a lesser charge.

A couple meets at the craps table in Las Vegas. She was a beautiful trapeze artist and he was a professional poker player -- with a secret. Did he take a gamble that led to murder?

The case against Michael Jackson’s doctor, Conrad Murray, is in the hands of the jury, who will decide whether he played a role in the death of the pop star.

A fatal car crash in Montana may not have been an accident after investigators find a revealing set of text messages.

Tom Foley is shocked to find himself the lead suspect in the case of his wife Darlene's murder. Thinking the case was over, the defense team is soon approached by a stranger with new evidence that would turn everything upside down.

A vacation in Aruba that morphed into a mystery, Robyn Gardner went missing and many presume she's dead.

2 years ago the young mother from Utah vanished. A husband under suspicion, a father-in-law under scrutiny, and investigators under pressure to solve this mystery at last.

10 Years ago, the accusation that Penn State Coach Jerry Sandusky sexually abused a child, came to the attention of Ray Gricar, the local district attorney. 3 years later Gricar went missing. His laptop was found but the hard drive was unreadable. Could Gricar’s disappearance be linked to the Sandusky scandal?

Millen, Georgia, a small industrial town so devastated by the Great Recession, its unemployment numbers peaked at 21% - more than twice the national average.

The story of an unsolved case involving a woman's love triangle that ended in her husband's fatal stabbing in front of their home, but more than two decades later, detectives have re-opened the case and need her help.

In the lead up to a murder trial, it begins to look like police arrested the wrong man.

Investigating the murder of a brilliant professor.