Ozzy gets transfered into a girl named Christine's body when she gives Hector mouth-to-mouth when he jumps off the high dive to impress her, while there Ozzy starts changing colors and acting like a girl also he is arrested because they think he is a virus.
Ozzy is still in Christine, using REM sleep (or Random Eye Movement). He calls Drix for help, thats when he learns he's gender morphing. When a cell from a certain gender goes to a body of another gender, that cell becomes that gender. With Drix's plan, and the help of another Drixinol cold pill in Christine called ""Drixina."" Ozzy might come back to Hector, and keep Christine from having pneumonia.
Everyone inside Hector forgets who Ozzy and Drix are when Hector experiences a concussion, forcing them to locate the site of the concussion, so they can reboot Hector's memories.
Hector eats a sausage that he barely cooked and gets sick which leads him to getting two worms in his the male worm dies after mating, but the female survives, so Ozzy tries to kill it along with a crazy captain and Drix.
After getting injured on a police case, Maria is sent home to rest for the week. She decided to use this time to work on a family reunion coming up for her. Drix notices a rip on the corner of Maria's family picture. Maria doesn't seem to want to talk about it but then Ricky comes in and starts putting the puzzle pieces together. Maria and Ricky share their past with Drix which turns out as Ricky being the family prankster. Maria lost his trust in him so Drix decides to help Ricky get it back. He allows him to be a private eye along with Ozzy with not so good results.
Hector uses a Nose spray to clear his nose, and Drix's Aunt appears. Suddenly, there's a drop in water in Hector and Ozzy thinks Drix's aunt is causing it.
Hector is super-sizing at fast-food resturaunts far too much, which gives Sticity, a bad cholestrial beatnik, the chance to kidnap a fat cell family's child, in an atempt to clog an artery. Can Ozzy and Drix (and the new navigational system, installed by Drix, named Backseat) return the huge blob to his parents in time?
While snowboarding with Travis, Hector crosses an off limits area. Hector starts to freeride, but falls and makes a rip in his trousers. This causes a virus named Cryle to drop Hector's temperature. Ozzy and Drix get ready for a day at the beach, but have to stop Cryle from making Hecotr die of hypothermia.
When Hector accidently breathes in lead, the lead gang cause him to make him feel ill. The Mayor then makes Hector eat cereal so he can bring in The Supplements.
